J. Mater. Chem. B, Vol. 3 (2015), 3677-3680

  • “Biodegradable PLGA nanoparticles loaded with hydrophobic drugs: confocal Raman microspectroscopic characterization”
  • Hu Yan, Yi-Fan Hou, Peng-Fei Niu, Ke Zhang, Tatsuya Shoji, Yasuyuki Tsuboi, Fang-Yao Yao, Li-Min Zhao and Junbiao Chang

  • J. Mater. Chem. B, Vol. 3 (2015), 3677-3680.
  • DOI: 10.1039/C5TB00434A

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Poly(lactic-co-glycolic acid) (PLGA) nanoparticles with bicyclol (5%) and 3-n-butyl-6-bromophthalid (Br-NBP) (3%) were prepared by an emulsification–solvent evaporation technique. The PLGA nanoparticles were, for the first time, successfully characterized by a laser trapping/confocal Raman spectroscopic technique using only individual PLGA nanoparticles. This technique allowed us to selectively obtain Raman spectra of optically trapped PLGA nanoparticles (∼10 nanoparticles) in solution. The Raman spectra of the PLGA nanoparticles loaded with hydrophobic drugs showed that these drugs were incorporated in the nanoparticles.